Article

Enrichment of Rare Variants in E3 Ubiquitin Ligase Genes in Early Onset Parkinson’s Disease

2021-03-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Dysfunction of the ubiquitination proteasome system (UPS) is important in the pathogenesis of Parkinson’s disease (PD). Patients with early onset PD (EOPD) are more susceptible to genetic factors. We systematically examined the overlaps between E3 ubiquitin ligase genes and EOPD. <bold>Methods</bold>A total of 695 EOPD patients were sequenced with whole exome sequ...

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Literature Corpus work: 24a771b7-daaa-5a74-a162-b2193e76bd21
DOI: 10.21203/rs.3.rs-262042/v1

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