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Article

AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance

2018-10-31

Abstract excerpt

<h4>Summary</h4> Hypoxia is a hall mark of solid tumor microenvironment and contributes to tumor progression and therapy failure. The developmentally important Notch pathway is implicated in cellular response of cancer cells to hypoxia. Yet, the mechanisms that potentiate Notch signaling under hypoxia are not fully understood. Hypoxia is also a stimulus for AMP-activated protein kinase (AMPK), a major cellular en...

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Literature Corpus work
291884b3-807e-5484-983e-21404fdf3b2d
DOI
10.1101/458489
Open publication

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