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Article

AMP-activated protein kinase promotes breast cancer stemness and drug resistance

23 Feb 2022

Abstract excerpt

Breast cancer stem cells (BCSCs) are a major cause of therapy resistance and tumour progression. Currently, their regulation is not entirely understood. Previous work from our laboratory demonstrated a context-specific pro-tumorigenic role for AMP-activated protein kinase (AMPK) under anchorage-deprivation and mammosphere formation, which are hallmarks of BCSCs. Therefore, we investigated the role of AMPK in the...

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PMID: 35195687
DOI: 10.1242/dmm.049203

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