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Article

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

19 Oct 2012

Abstract excerpt

Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells from the ER (endoplasmic reticulum) stress caused by severe hypoxia. Likewise, autophagy is a mechanism by which cancer cells can evade hypoxic cell death. In the present paper we report that the autophagy-initiating kinase ULK1 (UNC51-like kinase 1) is a...

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Autophagy in Disease and Therapy
Endoplasmic Reticulum Stress and Disease
Pancreatic function and diabetes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23078367
DOI: 10.1042/bj20120972

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