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Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin

2025-03-11

Abstract excerpt

<h4>Background</h4> Pancreatic ductal adenocarcinoma (PDAC) arises from distinct cellular origins, yet the extent to which DNA methylation patterns from normal pancreatic cells are preserved in tumor cells remains unclear. Identifying cell-of-origin signatures may enhance PDAC classification and therapeutic stratification. <h4>Objective</h4> To determine whether DNA methylation signatures in normal acinar and du...

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Literature Corpus work: 2881d666-de6d-5fd3-ac1b-6dbe8b7fa59e
DOI: 10.1101/2025.03.07.642043

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