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Article

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

12 Jul 2022

Abstract excerpt

Host genetic variation is an important determinant that predicts disease outcomes following infection. In the setting of highly pathogenic coronavirus infections genetic determinants underlying host susceptibility and mortality remain unclear. To elucidate the role of host genetic variation on sarbecovirus pathogenesis and disease outcomes, we utilized the Collaborative Cross (CC) mouse genetic reference...

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Identifiers

PMID: 35862771
DOI: 10.1128/mbio.01454-22

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