Mapping of susceptibility loci for Ebola virus pathogenesis in mice.

doi:10.1016/j.celrep.2024.114127

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Article

Mapping of susceptibility loci for Ebola virus pathogenesis in mice.

Cell reports - 28 May 2024

Schäfer Alexandra, Marzi Andrea, Furuyama Wakako, Catanzaro Nicholas J, Nguyen Cameron, Haddock Elaine, Feldmann Friederike, Meade-White Kimberly, Thomas Tina, Hubbard Miranda L, Gully Kendra L, Leist Sarah R, Hock Pablo, Bell Timothy A, De la Cruz Gabriela E, Midkiff Bentley R, Martinez David R, Shaw Ginger D, Miller Darla R, Vernon Michael J, Graham Rachel L, Cowley Dale O, Montgomery Stephanie A, Schughart Klaus, de Villena Fernando Pardo Manuel, Wilkerson Gregory K, Ferris Martin T, Feldmann Heinz, Baric Ralph S

Abstract excerpt

Ebola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans. Host genetic variation plays a critical role, yet the identity of host susceptibility loci in mammals remains unknown. Using genetic reference populations, we generate an F2 mapping cohort to identify host susceptibility loci that regulate EVD. While disease-resistant mice display minimal pathogenesis,...

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Identifiers

PMID: 38652660
DOI: 10.1016/j.celrep.2024.114127
PMCID: PMC11348656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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