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The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in <i>Mycobacteria</i>

2021-05-10

Abstract excerpt

Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis (Mtb). While heme is required for Mtb survival and virulence, it is also potentially cytotoxic. Since Mtb has the ability to both make and uptake heme, the de novo synthesis of heme and its acquisition from the host must be balanced in order to mitigate heme toxicity. However, the mechani...

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Identifiers and source

Literature Corpus work
28a930b7-b55e-5b9a-9308-efdf3259b29c
DOI
10.1101/2021.05.10.443464
Open publication

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