Article
Canalization of Phenotypes-When the Transcriptome is Constantly but Weakly Perturbed.
Molecular biology and evolution - 4 Jan 2023
Lu Guang-An, Zhang Jinning, Zhao Yixin, Chen Qingjian, Lin Pei, Tang Tian, Tang Zhixiong, Wen Haijun, Liufu Zhongqi, Wu Chung-I
Abstract excerpt
Recent studies have increasingly pointed to microRNAs (miRNAs) as the agent of gene regulatory network (GRN) stabilization as well as developmental canalization against constant but small environmental perturbations. To analyze mild perturbations, we construct a Dicer-1 knockdown line (dcr-1 KD) in Drosophila that modestly reduces all miRNAs by, on average, ∼20%. The defining characteristic of stabilizers is...
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