Article

Identification of molecular and clinical ALS subgroups based on TDP-43 loss of function molecular markers from population-based patient-derived iPS motor neurons

2025-12-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is a uniformly fatal neurodegenerative disease characterized by progressive cortical and spinal motor neuron loss, with most patients surviving only 2–5 years post-diagnosis. While approximately 10% of cases are familial (fALS), the remaining 90% are sporadic (sALS) with unknown genetic drivers. Importantly, clinical presentations are hete...

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Literature Corpus work: e575e036-f257-5640-8b0c-7dd464f7a42a
DOI: 10.64898/2025.12.28.696512

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