Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.

doi:10.1038/nature09327

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Article

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.

Nature - 9 Sept 2010

Bilgüvar Kaya, Oztürk Ali Kemal, Louvi Angeliki, Kwan Kenneth Y, Choi Murim, Tatli Burak, Yalnizoğlu Dilek, Tüysüz Beyhan, Cağlayan Ahmet Okay, Gökben Sarenur, Kaymakçalan Hande, Barak Tanyeri, Bakircioğlu Mehmet, Yasuno Katsuhito, Ho Winson, Sanders Stephan, Zhu Ying, Yilmaz Sanem, Dinçer Alp, Johnson Michele H, Bronen Richard A, Koçer Naci, Per Hüseyin, Mane Shrikant, Pamir Mehmet Necmettin, Yalçinkaya Cengiz, Kumandaş Sefer, Topçu Meral, Ozmen Meral, Sestan Nenad, Lifton Richard P, State Matthew W, Günel Murat

Abstract excerpt

The development of the human cerebral cortex is an orchestrated process involving the generation of neural progenitors in the periventricular germinal zones, cell proliferation characterized by symmetric and asymmetric mitoses, followed by migration of post-mitotic neurons to their final destinations in six highly ordered, functionally specialized layers. An understanding of the molecular mechanisms guiding these...

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PMID: 20729831
DOI: 10.1038/nature09327
PMCID: PMC3129007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.PMID 20729831Read ↗

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