Back to search

Article

Osteochondral Live Slices as Physiological in-vitro Model of the Human Joint for High-throughput Applications

2020-09-04

Abstract excerpt

<h4>Background: </h4> Current advances in musculoskeletal research yielded numerous new insights and therapy options for diseases of the joints but preclinical in-vitro testing is currently limited to self-manufactured 2D and 3D cell cultures only remotely mimicking the in-vivo situation in regards of tissue composition and cell configuration. While in-vivo animal models are a lot more lifelike, they are inherentl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d79c8e28-f852-5cf6-9011-e3a017332972
DOI
10.21203/rs.3.rs-68789/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Osteochondral Live Slices as Physiological in-vitro Model of the Human Joint for High-throughput ApplicationsDOI 10.21203/rs.3.rs-68789/v1
Models of ex vivo explant cultures: applications in bone researchSemantic proximity
Suitability of Porcine Chondrocyte Micromass Culture To Model Osteoarthritis in VitroSemantic proximity
Trauma induced tissue survival in vitro with a muscle-biomaterial based osteogenic organoid system: a proof of concept studySemantic proximity
Molecular Mechanism Study of Medial Open-Wedge High Tibial Osteotomy in Treating Medial Compartment Osteoarthritis of the Knee by Improving the Intra-Articular EnvironmentSemantic proximity
Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype.Semantic proximity
Modeling early changes associated with cartilage trauma into human-cell-laden hydrogel cartilage modelsSemantic proximity
Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slicesSemantic proximity
Macroscale mesenchymal condensation to study cytokine-driven cellular and matrix-related changes during cartilage degradation.Semantic proximity
Modelling Osteoarthritis pathogenesis through Mechanical Loading in an Osteochondral Unit-on-ChipSemantic proximity
Morphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated MicrogravitySemantic proximity
A systems biology approach to musculoskeletal tissue engineering : transcriptomic and proteomic analysis of cartilage and tendon cellsSemantic proximity
Engineering a reproducible 3D wound model with defined macrophage polarization and partial-thickness mechanical injurySemantic proximity
Select a neighboring publication to make it the new centre.