Article

Turning microglia neuroprotective: Towards connexin43-specific therapy of Alzheimer’s disease

2024-08-08

Abstract excerpt

Alzheimer’s disease (AD) is the major cause of senile dementia without effective therapeutic strategies. The fundamental role of microglia in AD pathology, particularly in the early stages, is well acknowledged, although cell-specific therapeutic targets were not identified. Here we show that microglial connexin 43 (Cx43) hemichannels controls microglial reactivity in AD, thus being a promising therapeutic target....

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Literature Corpus work: 288378d1-8ffc-5d78-8b04-d1fabcad72be
DOI: 10.1101/2024.08.06.606883

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