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Article

MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease.

Theranostics - 1 Jan 2021

Liang Chunmei, Zou Ting, Zhang Miaoping, Fan Weihao, Zhang Tianzhen, Jiang Yuling, Cai Yujie, Chen Feng, Chen Xiongjin, Sun Yuanhong, Zhao Bin, Wang Yan, Cui Lili

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and currently has no effective treatment. Mainstream research on the mechanisms and therapeutic targets of AD is focused on the two most important hallmarks, Aβ and Tau, but the results from clinical studies are not encouraging. Abnormal microglial polarization is a clear typical pathological feature in the progression of AD. Microglia can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33754051
DOI: 10.7150/thno.53418
PMCID: PMC7977456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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