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Article

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

30 Nov 2016

Abstract excerpt

BACKGROUND: Hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of Alzheimer's disease and related tauopathies. We previously demonstrated that the microglial activation induces tau hyperphosphorylation and cognitive impairment via activation of p38 mitogen-activated protein kinase (p38 MAPK) in the hTau mouse model of tauopathy that was deficient for microglial fractalkine receptor...

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PMID: 27974048
DOI: 10.1186/s13195-016-0221-y

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