Article

TransStop, a genomic language model for the pan-drug prediction of translational readthrough efficacy

2025-09-02

Abstract excerpt

<h4>Motivation</h4> Premature termination codons (PTCs) are a major cause of genetic diseases, but the efficacy of therapeutic readthrough agents is highly context-dependent. While linear models have shown promise in predicting readthrough efficiency, they may not fully capture the complex, non-linear interactions between sequence context and drug activity. <h4>Methods</h4> We developed TransStop, a transformer-...

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Literature Corpus work: 288298c1-9166-5574-8636-fc62056a5a49
DOI: 10.1101/2025.08.29.672857

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