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Article

StopKB: a comprehensive knowledgebase for nonsense suppression therapies.

Database : the journal of biological databases and curation - 12 Oct 2024

Haas Nicolas, Thompson Julie Dawn, Renaud Jean-Paul, Chennen Kirsley, Poch Olivier

Abstract excerpt

Nonsense variations, characterized by premature termination codons, play a major role in human genetic diseases as well as in cancer susceptibility. Despite their high prevalence, effective therapeutic strategies targeting premature termination codons remain a challenge. To understand and explore the intricate mechanisms involved, we developed StopKB, a comprehensive knowledgebase aggregating data from multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39395187
DOI: 10.1093/database/baae108
PMCID: PMC11470752

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