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Article

Defensin-driven viral evolution.

PLoS pathogens - 1 Nov 2020

Diaz Karina, Hu Ciara T, Sul Youngmee, Bromme Beth A, Myers Nicolle D, Skorohodova Ksenia V, Gounder Anshu P, Smith Jason G

Abstract excerpt

Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection despite neutralization of closely related microbes. We therefore hypothesized that defensins impose selective pressure during fecal-oral transmission. Upon passaging a defensin-sensitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33232373
DOI: 10.1371/journal.ppat.1009018
PMCID: PMC7723274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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