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High-dimensional single-cell analysis identifies cellular signatures associated with response to vedolizumab therapy in ulcerative colitis

2023-10-02

Abstract excerpt

<title>Abstract</title> <p>Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease of the gastrointestinal tract. When conventional therapy fails, patients need biologics such as vedolizumab (VDZ) to manage the disease. While VDZ has shown a compelling efficacy in UC, the rate of primary non-response amounts up to 50%. To uncover cellular and molecular cues that coordinate VDZ (non-)response, we perf...

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Literature Corpus work
5b7781de-ade7-5556-9890-17da865c48eb
DOI
10.21203/rs.3.rs-3348629/v1
Open publication

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High-dimensional single-cell analysis identifies cellular signatures associated with response to vedolizumab therapy in ulcerative colitisDOI 10.21203/rs.3.rs-3348629/v1
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