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T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients

29 Aug 2018

Abstract excerpt

BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are two distinct subgroups of idiopathic inflammatory myopathies, a chronic inflammatory disorder clinically characterized by muscle weakness and inflammatory cell infiltrates in muscle tissue. In PM, a major component of inflammatory cell infiltrates is CD8+ T cells, whereas in DM, CD4+ T cells, plasmacytoid dendritic cells, and B cells predominate. In this...

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PMID: 30157932
DOI: 10.1186/s13075-018-1688-7

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