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Genome-wide identification of cell type-specific susceptibility genes for Juvenile dermatomyositis through the analysis of N6-methyladenosine-associated SNPs.

Autoimmunity - 1 Dec 2024

Zhang Huan, Fan Kedi, Zhang Zhentao, Guo Yufan, Mo Xingbo

Abstract excerpt

Genome-wide association studies (GWASs) have pinpointed genetic loci associated with juvenile dermatomyositis (JDM). Functional genes within the GWAS loci may be cell type-specific, but their identity remains largely unknown. N6-methyladenosine (m6A) plays a pivotal role in regulating various cellular processes and is linked to autoimmune diseases. This study aimed to underscore the potential functional genes...

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PMID: 39447013
DOI: 10.1080/08916934.2024.2419117

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