Article
Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose).
Nature communications - 1 Mar 2021
Watanabe Kengo, Morishita Kazuhiro, Zhou Xiangyu, Shiizaki Shigeru, Uchiyama Yasuo, Koike Masato, Naguro Isao, Ichijo Hidenori
Abstract excerpt
Cells are under threat of osmotic perturbation; cell volume maintenance is critical in cerebral edema, inflammation and aging, in which prominent changes in intracellular or extracellular osmolality emerge. After osmotic stress-enforced cell swelling or shrinkage, the cells regulate intracellular osmolality to recover their volume. However, the mechanisms recognizing osmotic stress remain obscured. We previously...
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