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Article

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

2025-09-18

Abstract excerpt

<h4>SUMMARY</h4> The metabolic hallmarks of high-grade glioma (HGG) are not fully understood. Human brain tissue metabolomics revealed that the creatine synthesis pathway intermediate guanidinoacetate (GAA) accumulated ∼100-fold in HGGs relative to controls, which was caused by imbalanced activities of enzymes in this pathway. Glioma cells secreted GAA rather than using it to produce creatine, implicating an unex...

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Identifiers and source

Literature Corpus work
6fd65209-ac12-555c-aebf-5fef33eddcc8
DOI
10.1101/2025.09.15.676412
Open publication

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Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growthDOI 10.1101/2025.09.15.676412
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