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Analyzing patterns of tyrosine sulfation in naive antibody repertoires

2022-12-15

Abstract excerpt

HIV-1 infects a subset of immune cells identified by the receptor CD4 and a coreceptor, CCR5 or CXCR4. Previous studies revealed bnAbs against HIV-1 with antigen-binding sites mimicking binding sites of CCR5. Such antibodies are characterized by post-translationally sulfated tyrosines and anionic motifs in long complementarity determining regions 3 (CDR3s) of the heavy chains. Despite the great therapeutic potenti...

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Literature Corpus work
27ce2078-5efc-570f-9c81-107e9ced0376
DOI
10.1101/2022.12.13.520330
Open publication

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Analyzing patterns of tyrosine sulfation in naive antibody repertoiresDOI 10.1101/2022.12.13.520330
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