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The D Gene in CDR H3 Determines a Public Class of Human Antibodies to SARS-CoV-2

27 Apr 2024

Abstract excerpt

Public antibody responses have been found against many infectious agents. Structural convergence of public antibodies is usually determined by immunoglobulin V genes. Recently, a human antibody public class against SARS-CoV-2 was reported, where the D gene (IGHD3-22) encodes a common YYDxxG motif in heavy-chain complementarity-determining region 3 (CDR H3), which determines specificity for the receptor-binding...

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PMID: 38793718
DOI: 10.3390/vaccines12050467

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