Article
Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.
Frontiers in immunology - 1 Jan 2018
Haakenson Jeremy K, Huang Ruiqi, Smider Vaughn V
Abstract excerpt
Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique "stalk and knob" structure, with the knob protruding far out of the antibody surface, where it has the potential to bind antigens with concave epitopes. Activation-induced cytidine...
Topics
- Animals
- Antibodies
- Antibody Diversity
- Antigens
- Cattle
- Complementarity Determining Regions
- Evolution, Molecular
- Gene Expression Regulation
- Genetic Variation
- Organ Specificity
- Protein Binding
- Structure-Activity Relationship
- V(D)J Recombination