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Article

Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.

Frontiers in immunology - 1 Jan 2018

Haakenson Jeremy K, Huang Ruiqi, Smider Vaughn V

Abstract excerpt

Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique "stalk and knob" structure, with the knob protruding far out of the antibody surface, where it has the potential to bind antigens with concave epitopes. Activation-induced cytidine...

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Source

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Identifiers

PMID: 29915599
DOI: 10.3389/fimmu.2018.01262
PMCID: PMC5994613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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