Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate.

Abstract excerpt

Meningeal lymphatic vessels residing in the dural layer above the sinuses of the brain, meninges at the base of the brain, and near the cribriform plate have all been shown to drain fluid, cells, and antigens. We have previously reported that meningeal lymphatics near the cribriform plate undergo VEGFR3-dependent lymphangiogenesis during experimental autoimmune encephalomyelitis (EAE) to facilitate excess drainage...

Topics

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• Barrier Structure and Function Studies
• Cell Adhesion Molecules Research
• Cell Movement
• Homeostasis
• Leukocytes
• Lymphatic Vessels
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Phenotype

Identifiers and source

Literature Corpus work

e95f3a20-aa85-5eef-b2de-0bb888d321aa

DOI

10.21203/rs.3.rs-543816/v1