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Article

CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines.

Journal of cell science - 1 Sept 2010

Belly Agnès, Bodon Gilles, Blot Béatrice, Bouron Alexandre, Sadoul Rémy, Goldberg Yves

Abstract excerpt

The highly conserved ESCRT-III complex is responsible for deformation and cleavage of membranes during endosomal trafficking and other cellular activities. In humans, dominant mutations in the ESCRT-III subunit CHMP2B cause frontotemporal dementia (FTD). The decade-long process leading to this cortical degeneration is not well understood. One possibility is that, akin to other neurodegenerative diseases, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20699355
DOI: 10.1242/jcs.068817
PMCID: PMC3013364

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