Article

Evaluation of Bayesian Linear Regression Derived Gene Set Test Methods

2024-02-25

Abstract excerpt

Gene set tests can pinpoint genes and biological pathways that exert small to moderate effects on complex diseases like Type 2 Diabetes (T2D). By aggregating genetic markers based on biological information, these tests can enhance the statistical power needed to detect genetic associations. Our goal was to develop a gene set test utilizing Bayesian Linear Regression (BLR) models, which account for both linkage dis...

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Literature Corpus work: 2747144a-65ab-5c8f-bcc4-a7d2901a6887
DOI: 10.1101/2024.02.23.581726

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