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Article

Evaluation of Bayesian Linear Regression derived gene set test methods.

BMC genomics - 23 Dec 2024

Bai Zhonghao, Gholipourshahraki Tahereh, Shrestha Merina, Hjelholt Astrid, Hu Sile, Kjolby Mads, Rohde Palle Duun, Sørensen Peter

Abstract excerpt

BACKGROUND: Gene set tests can pinpoint genes and biological pathways that exert small to moderate effects on complex diseases like Type 2 Diabetes (T2D). By aggregating genetic markers based on biological information, these tests can enhance the statistical power needed to detect genetic associations. RESULTS: Our goal was to develop a gene set test utilizing Bayesian Linear Regression (BLR) models, which...

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Identifiers

PMID: 39716056
DOI: 10.1186/s12864-024-11026-2
PMCID: PMC11667926

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