Article
Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma.
PloS one - 1 Jan 2013
Wei Jun S, Johansson Peter, Chen Li, Song Young K, Tolman Catherine, Li Samuel, Hurd Laura, Patidar Rajesh, Wen Xinyu, Badgett Thomas C, Cheuk Adam T C, Marshall Jean-Claude, Steeg Patricia S, Vaqué Díez José P, Yu Yanlin, Gutkind J Silvio, Khan Javed
Abstract excerpt
Neuroblastoma is one of the most genomically heterogeneous childhood malignances studied to date, and the molecular events that occur during the course of the disease are not fully understood. Genomic studies in neuroblastoma have showed only a few recurrent mutations and a low somatic mutation burden. However, none of these studies has examined the mutations arising during the course of disease, nor have they...
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