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Article

Novel variants of the ATRX gene identified in MYCN non-amplified Neuroblastoma in Brazilian patients.

Clinics (Sao Paulo, Brazil) - 1 Jan 2025

Magalhães Gimenez Thamiris, Peralta Vanessa Pretes, Giorgi Ricardo Rodrigues, Morikawa Karina, Vince Carolina Camargo, Halley Nathalia, Siqueira Sheila Aparecida, Bendit Israel, Cristofani Lilian Maria, Filho Vicente Odone, Novak Estela Maria

Abstract excerpt

BACKGROUND: Neuroblastoma is one of the most common extracranial solid tumors in children and it frequently displays high heterogeneity throughout the course of the disease. It has previously been described those changes in the ATRX gene (Alpha Thalassemia/Mental Retardation, X-linked) are the most common recurring events in the indolent clinical subtype (∼30 %) of MYCN amplified neuroblastoma. There is no...

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Identifiers

PMID: 40286729
DOI: 10.1016/j.clinsp.2025.100652
PMCID: PMC12060459

Genes

MYCN
ATRX

Variants

Provenance

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