Article
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.
Scientific reports - 25 Apr 2018
Huang Liang-Chin, Ross Karen E, Baffi Timothy R, Drabkin Harold, Kochut Krzysztof J, Ruan Zheng, D'Eustachio Peter, McSkimming Daniel, Arighi Cecilia, Chen Chuming, Natale Darren A, Smith Cynthia, Gaudet Pascale, Newton Alexandra C, Wu Cathy, Kannan Natarajan
Abstract excerpt
Many bioinformatics resources with unique perspectives on the protein landscape are currently available. However, generating new knowledge from these resources requires interoperable workflows that support cross-resource queries. In this study, we employ federated queries linking information from the Protein Kinase Ontology, iPTMnet, Protein Ontology, neXtProt, and the Mouse Genome Informatics to identify key...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.