Back to search

Article

Machine Learning-based Phenotypic Imaging to Characterise the Targetable Biology of <i>Plasmodium falciparum</i> Male Gametocytes for the Development of Transmission-Blocking Antimalarials

2023-04-23

Abstract excerpt

Preventing parasite transmission from humans to mosquitoes is recognised to be critical for achieving elimination and eradication of malaria. Consequently developing new antimalarial drugs with transmission-blocking properties is a priority. Large screening campaigns have identified many new transmission-blocking molecules, however little is known about how they target the mosquito-transmissible Plasmodium falcip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
94e4230a-8882-5cd0-aa24-9c77086ad4f2
DOI
10.1101/2023.04.22.537818
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Machine Learning-based Phenotypic Imaging to Characterise the Targetable Biology of <i>Plasmodium falciparum</i> Male Gametocytes for the Development of Transmission-Blocking AntimalarialsDOI 10.1101/2023.04.22.537818
Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarialsSemantic proximity
A machine learning approach to define antimalarial drug action from heterogeneous cell-based screensSemantic proximity
4D live-cell imaging of microgametogenesis in the human malaria parasite <i>Plasmodium falciparum</i>Semantic proximity
Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparumSemantic proximity
A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds.Semantic proximity
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV Pathogen BoxSemantic proximity
Analysis of the <i>Leishmania mexicana</i> promastigote cell cycle using imaging flow cytometry provides new insights into cell cycle flexibility and events of short durationSemantic proximity
Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput AssaySemantic proximity
Structure and function of <i>Plasmodium</i> actin II in the parasite mosquito stagesSemantic proximity
Photoaffinity labeling of protein targets in a complex metazoan: proof-of-concept using a probe for <i>Schistosoma mansoni</i> tubulinSemantic proximity
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.Semantic proximity
Sub-minute phosphoregulation of cell-cycle systems during <i>Plasmodium</i> gamete formationSemantic proximity
Select a neighboring publication to make it the new centre.