Article

Increased response to immune checkpoint inhibitors with dietary methionine restriction

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Dietary methionine restriction, defined as reduction of methionine intake by around 80%, reproducibly decreases tumor growth and synergizes with cancer therapies. Here, we combined dietary methionine restriction with immune checkpoint inhibitors in a model of colon adenocarcinoma. In vitro , we observed that methionine restriction increased the expression of MHC-I and PD-L1 in both mouse and hu...

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Literature Corpus work: 270ad824-07af-56da-a9ae-02e7db8e3c60
DOI: 10.1101/2023.04.05.535695

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