Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose</bold> Approximately one-third of colorectal cancer cases involve the rectum, where radiation therapy is an integral part of the treatment of this disease. However, KRAS mutations are associated with poor clinical outcomes and lower therapeutic responses. Previous studies suggest that KRAS mutations may alter the balance of metabolites in the methionine cycle. This stud...

Topics

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• Apoptosis
• Autophagy
• Colorectal Neoplasms
• Effects of Radiation Exposure
• Metformin
• Mice
• Mutation
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

5e278e92-ce9b-5a8f-86b4-2623a351276d

DOI

10.21203/rs.3.rs-6497576/v1