Article

Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in TSC2-Deficient and Cancer Cells

2025-04-04

Abstract excerpt

<h4>Background: </h4> /Objectives: Ferroptosis, an iron-dependent form of cell death, shows promise as a target for therapy-resistant cancers that exhibit increased iron metabolism. Ferroptosis is primarily characterised by lipid peroxidation within cell membranes. However, many cancers evade ferroptosis by upregulation of specialised ferroptosis defence mechanisms. This study investigates ferroptosis susceptibili...

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Literature Corpus work: 26f1e9f6-bc44-5a42-ab2d-f45f23eaf6b0
DOI: 10.20944/preprints202504.0343.v1

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