Article

Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in <em>TSC2</em>-Deficient and Cancer Cells

2025-08-20

Abstract excerpt

<h4>Background: </h4> /Objectives: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and holds promise as a therapeutic strategy against cancers with elevated iron metabolism. However, many tumors evade ferroptosis through the upregulation of specialized antioxidant defense mechanisms. Here, we investigated ferroptosis susceptibility and resistance mechanisms in TSC models...

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Literature Corpus work: e48dc6b0-46b7-5ccd-b6cc-cb35df3b070a
DOI: 10.20944/preprints202504.0343.v2

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