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Article

Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy.

Cell death & disease - 7 May 2026

Tabnak Peyman, Ebrahimnezhad Mohammad, HajiEsmailPoor Zanyar

Abstract excerpt

Ferroptosis, an iron-dependent programmed cell death pathway driven by lipid peroxidation, offers a transformative approach to cancer therapy by exploiting unique cellular vulnerabilities. This comprehensive review elucidates the intricate molecular mechanisms of ferroptosis and their modulation by genetic mutations across diverse malignancies, including lung, hematological, liver, colorectal, breast, glioma,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42098074
DOI: 10.1038/s41419-026-08796-w
PMCID: PMC13315318

Genes

EGFR
GPX4
IDH1
KEAP1
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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