FSP1 and NRF2 independently contribute to ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma

Abstract excerpt

<title>Abstract</title> <p>Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood. To address this issue, we conducted a thorough investigation of the genomic and transcriptomic data derived from hundreds of human cancer cell lines and primary t...

Topics

Open a Topic to create a Post that cites this publication.

• Cancer-related molecular mechanisms research
• Epigenetics and DNA Methylation
• Ferroptosis and cancer prognosis
• Kelch-Like ECH-Associated Protein 1
• Lung Neoplasms
• Mutation
• NF-E2-Related Factor 2
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

a093971c-7243-5082-bc22-5d6694261027

DOI

10.21203/rs.3.rs-2921779/v1