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The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection

12 Oct 2023

Abstract excerpt

BACKGROUND: Existing methods to detect tumor signal in liquid biopsy have focused on the analysis of nuclear cell-free DNA (cfDNA). However, non-nuclear cfDNA and in particular mitochondrial DNA (mtDNA) has been understudied. We hypothesize that an increase in mtDNA in plasma could reflect the presence of cancer, and that leveraging cell-free mtDNA could enhance cancer detection. RESULTS: We survey 203 healthy...

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PMID: 37828498
DOI: 10.1186/s13059-023-03074-w

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