Article

ATP13A4 upregulation drives the elevated polyamine transport system in the breast cancer cell line MCF7

2023-04-03

Abstract excerpt

Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an upregulated polyamine transport system (PTS). So far, the polyamine transporters contributing to the elevated levels of polyamines in cancer cells have not yet been described, despite the fact that polyamine transport inhibitors are considered for cancer therapy. He...

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Literature Corpus work: 26b2676c-0e86-5372-b0a7-e96cfdf2dc56
DOI: 10.1101/2023.03.31.534207

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