ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.

doi:10.1093/cvr/cvae068

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Article

ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.

Cardiovascular research - 29 May 2024

Liu Bin, Azfar Mujahid, Legchenko Ekaterina, West James A, Martin Shaun, Van den Haute Chris, Baekelandt Veerle, Wharton John, Howard Luke, Wilkins Martin R, Vangheluwe Peter, Morrell Nicholas W, Upton Paul D

Abstract excerpt

AIMS: Potential loss-of-function variants of ATP13A3, the gene encoding a P5B-type transport ATPase of undefined function, were recently identified in patients with pulmonary arterial hypertension (PAH). ATP13A3 is implicated in polyamine transport but its function has not been fully elucidated. In this study, we sought to determine the biological function of ATP13A3 in vascular endothelial cells (ECs) and how...

Topics

Animals
Humans
Mice
Apoptosis
Biological Transport
Cell Proliferation
Cells, Cultured
Disease Models, Animal
Endosomes
Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypertension, Pulmonary

Mice, Inbred C57BL

Phenotype

Polyamines

Proton-Translocating ATPases

Pulmonary Arterial Hypertension

Pulmonary Artery

Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38626311
DOI: 10.1093/cvr/cvae068
PMCID: PMC11135649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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