Article
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.
The Journal of biological chemistry - 1 Jan 2000
Hamouda Norin Nabil, Van den Haute Chris, Vanhoutte Roeland, Sannerud Ragna, Azfar Mujahid, Mayer Rupert, Cortés Calabuig Álvaro, Swinnen Johannes V, Agostinis Patrizia, Baekelandt Veerle, Annaert Wim, Impens Francis, Verhelst Steven H L, Eggermont Jan, Martin Shaun, Vangheluwe Peter
Abstract excerpt
Polyamines, such as putrescine, spermidine, and spermine, are physiologically important polycations, but the transporters responsible for their uptake in mammalian cells remain poorly characterized. Here, we reveal a new component of the mammalian polyamine transport system using CHO-MG cells, a widely used model to study alternative polyamine uptake routes and characterize polyamine transport inhibitors for...
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