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Article

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies.

Cancer cell - 8 Jun 2020

Gurusamy Devikala, Henning Amanda N, Yamamoto Tori N, Yu Zhiya, Zacharakis Nikolaos, Krishna Sri, Kishton Rigel J, Vodnala Suman K, Eidizadeh Arash, Jia Li, Kariya Christine M, Black Mary A, Eil Robert, Palmer Douglas C, Pan Jenny H, Sukumar Madhusudhanan, Patel Shashank J, Restifo Nicholas P

Abstract excerpt

T cells are central to all currently effective cancer immunotherapies, but the characteristics defining therapeutically effective anti-tumor T cells have not been comprehensively elucidated. Here, we delineate four phenotypic qualities of effective anti-tumor T cells: cell expansion, differentiation, oxidative stress, and genomic stress. Using a CRISPR-Cas9-based genetic screen of primary T cells we measured the...

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Source

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Identifiers

PMID: 32516591
DOI: 10.1016/j.ccell.2020.05.004
PMCID: PMC10323690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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