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Glucagon-like peptide-1 receptor activation and mental health: a drug-target Mendelian randomization study

2025-02-13

Abstract excerpt

Concerns have been raised about the psychiatric safety of glucagon-like peptide-1 receptor (GLP-1R) agonists, but trial evidence suggests that they ameliorate depressive symptoms. We aimed to assess the associations of GLP-1R activation with mental health well-being and the risk of mental health disorders and substance use disorders. We performed drug-target Mendelian randomization and colocalization analyses usin...

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Literature Corpus work
268f1176-6b0e-5567-b918-6639fff757f2
DOI
10.1101/2025.02.12.25322150
Open publication

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Glucagon-like peptide-1 receptor activation and mental health: a drug-target Mendelian randomization studyDOI 10.1101/2025.02.12.25322150
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