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Article

Causal association between glucagon-like peptide-1 receptor agonists and mental disorders: insight from genetic and real-world evidence.

Journal of affective disorders - 15 Jun 2026

Ouyang Chenhao, Zhang Xiaoyue, Zhang Minghai, Miao Yan, Zhu Zicheng, Zeng Yunting, Ban Hong, Wu Yuting, Peng Nanqin, Ling Jitao, Li Chen, Zhang Deju, Yu Peng, Zhang Jing, Liu Xiao, Huang Tongsheng

Abstract excerpt

BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), recognized for hypoglycemic and weight reduction efficacy, have been debated regarding potential association with mental disorders. This study sought to elucidate causal relationship between GLP-1RAs and mental disorders. METHOD: Two-sample Mendelian randomization, Linkage Disequilibrium Score Regression (LDSC) and Bayesian co-localization were...

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PMID: 41713610
DOI: 10.1016/j.jad.2026.121452

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