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Article

Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study.

Journal of advanced research - 1 Apr 2025

Zhao Guorui, Lu Zhe, Liao Yundan, Sun Yaoyao, Zhang Yuyanan, Kang Zhewei, Feng Xiaoyang, Sun Junyuan, Yue Weihua

Abstract excerpt

INTRODUCTION: Psychiatric disorders present a substantial global public health burden with limited drug options. The gut-brain axis connects inflammatory bowel diseases and psychiatric disorders, which often have comorbidities. While some evidence hints at anti-inflammatory drugs aiding in treating psychiatric conditions, the specific effects of intestinal anti-inflammatory drugs remain unclear. OBJECTIVES: This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38735387
DOI: 10.1016/j.jare.2024.05.002
PMCID: PMC11976564

Genes

TPMT
ACAT1

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