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Polymeric Pathogen-like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity to Influenza A Virus

2020-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Eliciting durable and protective T cell-mediated immunity in the respiratory mucosa remains a significant challenge. Polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) loaded with TLR agonists mimic biophysical properties of microbes and hence, simulate pathogen-pattern recognition receptor interactions to safely and effectively stimulate innate immune responses. We...

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Identifiers and source

Literature Corpus work
26883741-8665-559c-8365-b631c108c6c7
DOI
10.1101/2020.07.10.197749
Open publication

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