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Article

Antigen-dependent interplay of formulation, systemic innate responses, and antibody responses to multi-component replicon RNA vaccination

9 Jun 2025

Abstract excerpt

Replicon RNA (repRNA) vaccines are a transformative tool in combating infectious diseases, eliciting robust immune responses at lower doses. However, systemic inflammatory responses to lipid nanoparticle (LNP)-formulated RNA vaccines may compromise safety and efficacy. repRNA vaccines delivered with cationic nanocarriers like LION offer a promising alternative by localizing innate immune responses required to...

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PMID: 40606648
DOI: 10.1016/j.omtn.2025.102595

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